Healthcare Supplement
Spermidine Trihydrochloride 3HCL Powder
Kintainutri® Factory Supply Wholesale Spermidine Trihydrochloride 3HCL
Kintainutri® specializes in providing high-purity spermidine trihydrochloride raw materials, with a stable purity of over 98%. We employ advanced microbial fermentation technology in our production process, conducted entirely in GMP-compliant cleanrooms, and utilize a rigorous end-to-end quality control system to ensure that the purity, safety, and consistency of each batch of products meet international standards.
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Spermidine trihydrochloride is the hydrochloride form of spermidine, which is more stable and more water-soluble. Due to its higher water solubility and stability, spermidine trihydrochloride is widely used in dietary supplements to support autophagy, help cells repair themselves, and delay aging.
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Spermidine Trihydrochloride production Process
Purity is non-negotiable. The synthesis process of Our High Purity Spermidine Trihydrochloride powder is generally divided into the following steps.
1. First, spermidine is obtained by reaction of synthetic raw materials. Spermidine is a colourless crystal which can be obtained by synthesising the raw material under appropriate reaction conditions.
2. Next, we let spermidine is reacted with hydrochloric acid. Hydrochloric acid is a common inorganic acid with strong acidity. Under suitable reaction conditions, spermidine reacts with hydrochloric acid to form spermidine trihydrochloride. Spermidine trihydrochloride is a white crystal, which is soluble in water.
3. Finally react spermidine trihydrochloride with hydrochloric acid to obtain spermidine trihydrochloride. Spermidine trihydrochloride is a white crystal with high purity and stability.
During the whole synthesis process, the reaction conditions, reaction time and molar ratio of reactants we need to be controlled to ensure the quality and yield of the synthesised product. In addition, we proper reaction solvent selection and reaction temperature control are required to improve the synthesis efficiency and product purity.
Spermidine Trihydrochloride 3HCL Powder COA
Spermidine Trihydrochloride 3HCL Powder Benefits
1. Promote autophagy
Spermine trihydrochloride has the ability to induce physiological autophagy. By mimicking the fasting effect, it activates AMPK and inhibits mTOR signaling to initiate autophagy, helping to clear toxic substances and reduce oxidative stress and inflammation. At the same time, it affects the expression of autophagy-related genes by regulating the acetylation levels of proteins and chromatin, further enhancing the cell's self-renewal and anti-aging capabilities.
In yeast, fruit fly, and mouse models, spermidine supplementation has been shown to significantly extend lifespan by enhancing the autophagy pathway, and preliminary human studies also suggest that a daily dose of 40 mg can safely increase autophagy markers. Through comprehensive activation of autophagy, spermidine trihydrochloride is considered to have potential supporting roles in the prevention of neurodegenerative diseases and metabolic disorders.
Reference: lifespan.io; sciencedirect.com; pmc.ncbi.nlm.nih.gov
2. Antioxidant and DNA protection
This ingredient maintains health through multiple antioxidant and cellular protection mechanisms. It directly neutralizes free radicals, alleviates oxidative stress, and binds to DNA to form a stable complex, protecting the integrity of genetic material and thus helping to maintain genome stability. Simultaneously, it enhances mitochondrial biogenesis, optimizes energy metabolism, and reduces reactive oxygen species (ROS) production, thereby improving cellular energy supply and anti-aging capabilities.
Furthermore, spermidine can reduce chronic inflammatory responses by inhibiting the NF-κB signaling pathway and downregulating the expression of pro-inflammatory factors. These synergistic mechanisms enable it to comprehensively support cellular function under stress, acting as a "cytoprotective agent."
Reference: glycanage.com; zxchem.com; nypost.com
3. Metabolic and physiological regulatory
Spermine trihydrochloride provides broad support for overall health by regulating various metabolic and physiological processes: it helps improve endothelial function, regulates blood pressure and cholesterol, thereby protecting the cardiovascular system; in terms of neurohealth, it promotes the clearance of β-amyloid protein, supporting cognitive function and memory.
Simultaneously, it enhances the body's defense and repair capabilities by increasing immune cell activity and maintaining polyamine metabolic balance. Multiple studies and epidemiological data further demonstrate that long-term spermine intake is associated with extended healthy lifespan and reduced mortality risk, reflecting its comprehensive health benefits through multi-system synergy.
Reference: nypost.com; endocrine-abstracts.org; pmc.ncbi.nlm.nih.gov; lifespan.io
What is Spermidine Trihydrochloride used for?
As an important chemical raw material, spermidine hydrochloride has a wide range of uses and applications in many fields. The following are the common uses and applications of spermidine hydrochloride in various fields:
Spermine hydrochloride, as a supplement, has applications covering multiple dimensions of health maintenance, including delaying aging, supporting reproductive health, protecting cardiovascular and metabolic functions, and maintaining neurocognitive function. In sports nutrition, it can promote muscle repair, and in skin and hair health, it can delay hair follicle aging. Products are mostly available in capsule or powder form and are often combined with other functional ingredients.
Spermidine Trihydrochloride Side Effects
Spermidine Trihydrochloride Toxic
In vitro genotoxicity tests and a 90-day rat toxicity study assessed spermidine trihydrochloride as not exhibiting genotoxicity, with a subchronic no-observed-adverse-effect level (NOAEL) of 728 mg/kg body weight/day. As an endogenous polyamine that can be synthesized in the human body and produced by gut microbiota, spermidine has a long history of safe dietary use.
Reference: https://pubmed.ncbi.nlm.nih.gov/38163454/
Clinical studies have further confirmed that daily supplementation with 40 mg for 28 consecutive days did not result in significant changes in any of the subjects' physiological indicators, no related adverse events occurred, and the polyamine concentration in the body remained stable, demonstrating good safety and tolerability. Overall toxicological data support its wide safety margin in humans.
Kintainutri® Spermidine Trihydrochloride Advantages
High Purity and Potency:
Our spermine hydrochloride has 99% purity and is rigorously tested by HPLC and NMR to ensure consistent quality and biological activity.
Multi-Industry Applications:
Nutraceuticals (cell life extension and metabolism support)
Cosmetics (anti-aging and hair growth formulations)
Pharmaceutical research (neuroprotection, cancer research and drug development)
Strict Quality Control:
Manufactured in a GMP certified facility with full traceability and available with COA, MSDS and full testing for heavy metals, residual solvents and endotoxins.
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Shipping & Packaging
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● Packaging: Inside food grade bag, outer aluminum foil bag.25kg use double-layer plastic container/fiber drum.Or your choice.● OEM Service Available: Customized packaging available, click here to know more.● Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA● American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.● Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.Please contact us and we will guide you with an easy and professional way for your order.
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